Scientific Evidence – The Foundation of Efficacy and Safety

Filipovic I, Ostojic O, Vekovic V, Mihajlovic S, Caminati M, Zivkovic Z. Efficacy of Specially Formulated Combination Three Probiotic Strains with Vitamin D3 and Zn in Children with Atopic Dermatitis. American Journal of Pediatrics. 2023;9(4):186-192. doi: 10.11648/j.ajp.20230904.11

Atopic Dermatitis In Children

Our study confirmed that regular treatment with this specific probiotic mixture significantly decreased pruritus and sleep problems and improved quality of life in highly atopic children with severe atopic dermatitis.
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Protic D, Bascarevic D, Dimitrijevic S, et al. Microbiome modulation and behavioural improvements in children with fragile X syndrome following probiotic intake: A pilot study. Scientific Reports. 2026;16:560. doi: 10.1038/s41598-025-29896-1

Fragile X Syndrome (FXS)

This pilot study provides initial evidence that probiotics may modulate structural and functional properties of the GM, with potential links to improved behavioural outcomes in children with FXS.
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Barac B, Lukovic S, Kojic T, Radnic TZ, Bibic A. Therapeutical efficacy of immunobiotics in patients with newly diagnosed rheumatoid arthritis. Journal of Infection in Developing Countries. 2025;19:1861-1868. doi: 10.3855/jidc.21182

Rheumatoid Arthritis

This randomized controlled trial demonstrates that adjunctive probiotic supplementation alongside conventional DMARD therapy significantly improves clinical outcomes in newly diagnosed rheumatoid arthritis patients over a period of 12 months.
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